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By Frederick F. Holmes M.D. (auth.)

ISBN-10: 3642821014

ISBN-13: 9783642821011

ISBN-10: 3642821030

ISBN-13: 9783642821035

The lifetime of a man or woman is finite, and all people age (see Fries 1980). it really is tough to split the consequences of ailment on organs and tissues from these anticipated of getting older. this can be quite actual for vascular and degenerative tactics, for which there aren't any transparent barriers among getting older and ailment. Morbidity and mortality from middle affliction and stroke are most likely due either to disorder and to adjustments of getting older. For melanoma, the second one prime explanation for loss of life in the United States, the placement is kind of diversified; melanoma is obviously a ailment and isn't a metamorphosis anticipated with getting older. melanoma occurrence raises virtually logarithmically after age forty. within the usa approximately one-half of all circumstances of melanoma are clinically determined after age sixty five, even supposing these over sixty five include lower than one-eighth of the inhabitants. hence, melanoma is particularly a lot a ailment of the aged. There are not less than purposes for this: first, the lengthy publicity to cancer-inducing brokers, and moment, the waning energy of immune defenses opposed to cancer.

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Single drugs, usually an alkylating agent, and lately multi-agent treatment schemes have been surprisingly effective in some reported studies (Tobias and Griffiths 1976; Bagley et al. 1972; Young et al. 1978; Katz et al. 1981). Local There are not enough cases to provide comparisons of the two time periods or even to give a reliable survival curve for the 85-94 age-group for the more recent period. Only 20%-25% of ovarian cancers are diagnosed when locally confined. However, when this is the case most women are cured, and in the 75-84 age-group 5-year survival approaches that of the general population (Fig.

1976) pointed out the increase in incidence of endometrial carcinoma in eight areas of the United States during the 1970s. A number of studies were published over a period of several years, and were vigorously criticized or defended in editorials, and some semblence '00 50-54 55-58 lo-e4 l5-1e 70-74 AGE IN YEARS 75-78 10-14 85- Fig. 1. Incidence of uterine corpus cancer in USA 1973-1977 Local 35 of truth may finally have emerged (Greenwald et al. 1977; Weiss et al. 1979; Shapiro et al. 1980; Weiss-1978; Jick et al.

Death from the disease after 5 years is a factor, and late recurrence is not unusual. Obviously there is a great need to develop means of systemic therapy, particularly as adjuvant to potentially curative surgery, in this stage of the disease. I :) 30 20 Fig. 3. I :) 30 20 Fig. 4. Years survival by age and time groups for distantly spread colorectal cancer 10 , \ \ \ \ \ \ '\ '\ '\ '\ '\ '\ '\ 0 '\ 3 65-74 3 75-64 3 85-94 5 26 Colon and Rectum Distant Just about 15% of all cases of colorectal cancer are diagnosed at this stage, with little variation among the three age groups and between the two time periods.

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Aging and Cancer by Frederick F. Holmes M.D. (auth.)


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