By Novartis Foundation
With the ever-increasing upward push in existence expectancy, there's an pressing have to enhance our figuring out of the connection among growing older and the pathogenesis of age-related illnesses so that it will establish more desirable technique of prevention, amelioration and administration of such illnesses. moreover, there's a have to decrease the social and monetary influence of the getting old inhabitants. Age-related morbidity and mortality vary dramatically between contributors; this ebook focusses on person transformations in susceptibility to age-related issues.
It comprises contributions from major specialists within the box on themes such as:
age-related pathology within the mind, age-related procedures in stem cells, and age-related results at the immune process and in bone, muscle and cardiovascular tissue. For all people with an curiosity within the biology of getting old, this can be obligatory reading.Content:
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Extra info for Ageing Vulnerability: Causes and Interventions: Novartis Foundation Symposium 235
Biochemistry 38:7609^7616 Kang J, Lemaire HG, Unterbeck A et al 1987 The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733^736 Kong J, Xu Z 1998 Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J Neurosci 18:3241^3250 Lee JY, Mook-Jung I, Koh JY 1999 Histochemically reactive zinc in plaques of the Swedish mutant b-amyloid precursor protein transgenic mice.
GSH AND IRON IN PARKINSON’S DISEASE 25 Cerami: I thought that normal melanin production is an enzymatic process: it is not iron-mediated. Andersen: No, but iron is taken up by the melanin-containing cells and can be oxidized to ferric iron. The melanin may be involved in iron-catalysed oxidative events. References Gorell JM, Johnson CC, Rybicki BA et al 1999 Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson’s disease. Neuro Tox 20:239^248 Kang Y, Viswanath V, Jha N, Quiao XX, Mo J-Q, Andersen JK 1999 Neuronal glutamyl cysteine synthetase mRNA expression in the murine brain: comparison to regional speci¢c enzyme activity and GSH levels.
Robert: A few years ago at any meeting on AD, there were many people who thought that shorter Ab was good for the neurons. Over a decade or so the ratio of people who thought it was good versus those who thought it was bad has progressively shifted in favour of those who think it was bad. What about the shorter variant? Does it have neurotrophic activity? Secondly, how do you explain the 10% of familial AD cases? Bush: The very ¢rst papers about the neurotoxicity of Ab were published by Bruce Yankner in 1989 and 1990.
Ageing Vulnerability: Causes and Interventions: Novartis Foundation Symposium 235 by Novartis Foundation