By Th. Büchner (auth.), W. Hinterberger, A. J. Barrett, K. Lechner, E. Deutsch (eds.)
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Extra info for 11th Annual meeting of the EBMT: European Cooperative Group for Bone Marrow Transplantation
Lym. oth. grd. grd. grd. grd. D MC 9 5 1 0 1 9 4 110 22 13 10 51 14 (D=diagnosis, A=responding relapse, B=resistant relapse) Inrounology 34 Unknawn 20 (NHL ~nly)T-cell 16 B-cell 3 Null 8 True histiocytic Conditioning Chemotherapy: HD 28 NHL 62 1 NHL 19 HD Chemo & DXR: Purging had marrow purged 10/llO with T monoclonal l with 4 HC 2 with Asta 7 7 Results Haemopoietic recovery is shown in relation to dose in Table 1. Table 1. NHL & HD (llO) Mean Time Mean time Nucl. ,.. 0 X 10 /1, platelets 750 X 10 /1.
M. Marmont 1 1 2 3 Division of Hematology, Genova, Italy National Cancer Institute, Milan, Italy Division ofHematology, Bozen, Italy The optimal management of pat i ents who deve l op progressive or recurrent disease after primary chemotherapy remai ns to be estab l i shed. New salvageregimens have been shown tobe able to control the disease in many relapsed patients. There is, however, a sizable group of truly malignant patients who either fail to achieve a remission or relapse after few months and respond poorly even to powerful salvage regimens such as CEP (CCNU+Etoposide+prednimustine).
Three patients had fever of unknown origin. No lifethreatening or lethal infection complications occurred. Conclusion This heterogenaus group of 18 consecutive patients was treated according to a standardized BMT protocol aimed to reduce early posttransplant complications. In spite of the fact that 15 patients had at least one (8 of them 2-3) risk factors related to high early mortality (1,2), only two early death occurred. The low incidence of moderate or severe acute GvHO as well as the absence of interstitial pneumonia and lethal infections observed in this small patients group is presumed to be related to the rigorous isolation/decontamination conditions, the reduction of radiation toxicity and GvH prophylaxis with cyclosporin-A.
11th Annual meeting of the EBMT: European Cooperative Group for Bone Marrow Transplantation by Th. Büchner (auth.), W. Hinterberger, A. J. Barrett, K. Lechner, E. Deutsch (eds.)